Version 5.4
Homo sapiens Gene: ATG4D
Summary
InnateDB Gene IDBG-27678.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4D
Gene Name autophagy related 4D, cysteine peptidase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130734
Encoded Proteins
IDBP-27680
ATG4 autophagy related 4 homolog D (S. cerevisiae)
IDBP-761183
IDBP-762651
IDBP-762293
IDBP-764669
IDBP-764702
IDBP-763128
IDBP-761084
IDBP-763641
IDBP-764115
IDBP-764033
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10543895-10553418
Strand Forward strand
Band p13.2
Transcripts
ENST00000309469 ENSP00000311318
ENST00000588857 ENSP00000468290
ENST00000589753 ENSP00000466439
ENST00000586477 ENSP00000467223
ENST00000588667 ENSP00000467407
ENST00000585437 ENSP00000467694
ENST00000586863 ENSP00000465089
ENST00000586417 ENSP00000467906
ENST00000590096
ENST00000585752 ENSP00000465716
ENST00000588972 ENSP00000466759
ENST00000587256 ENSP00000468780
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002820
View Gene Order
ENSBTAG00000010727
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt Q86TL0
TrEMBL K7EKP6 Q969K0
UniProt Splice Variant
Entrez Gene 84971
UniGene Hs.512799
RefSeq NM_001281504 NM_032885
HUGO HGNC:20789
OMIM 611340
CCDS CCDS12241
HPRD 07005
IMGT
EMBL AC011461 AJ312332 BC007639 BC016845 BC068992 CH471106
GenPept AAH07639 AAH16845 AAH68992 CAC85951 EAW84116
RNA Seq Atlas 84971

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca