InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGCC

Summary

InnateDB Protein

IDBP-27787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGCC

Protein Name

chromosome 13 open reading frame 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368664

InnateDB Gene

IDBG-27785 (RGCC)

Protein Structure

UniProt Annotation

Function

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269PubMed:11687586, ECO:0000269PubMed:17146433, ECO:0000269PubMed:19158077, ECO:0000269PubMed:22163048}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.

Disease Associations

Tissue Specificity

Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues. {ECO:0000269PubMed:11687586, ECO:0000269PubMed:15713436}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity
GO:0070412	R-SMAD binding

Biological Process

GO:0001100	negative regulation of exit from mitosis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0003331	positive regulation of extracellular matrix constituent secretion
GO:0006956	complement activation
GO:0008285	negative regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016525	negative regulation of angiogenesis
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032967	positive regulation of collagen biosynthetic process
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045840	positive regulation of mitosis
GO:0050710	negative regulation of cytokine secretion
GO:0050715	positive regulation of cytokine secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051496	positive regulation of stress fiber assembly
GO:0071158	positive regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia
GO:0071850	mitotic cell cycle arrest
GO:0072537	fibroblast activation
GO:0090272	negative regulation of fibroblast growth factor production
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization
GO:1901991	negative regulation of mitotic cell cycle phase transition
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000573	positive regulation of DNA biosynthetic process