InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RGCC

Summary

InnateDB Gene

IDBG-27785.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGCC

Gene Name

regulator of cell cycle

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000102760

Encoded Proteins

IDBP-27787

chromosome 13 open reading frame 15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:41457559-41470882

Strand

Forward strand

Band

q14.11

Transcripts

ENST00000379359	ENSP00000368664
ENST00000487837

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity
GO:0070412	R-SMAD binding

Biological Process

GO:0001100	negative regulation of exit from mitosis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0003331	positive regulation of extracellular matrix constituent secretion
GO:0006956	complement activation
GO:0008285	negative regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016525	negative regulation of angiogenesis
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032967	positive regulation of collagen biosynthetic process
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045840	positive regulation of mitosis
GO:0050710	negative regulation of cytokine secretion
GO:0050715	positive regulation of cytokine secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051496	positive regulation of stress fiber assembly
GO:0071158	positive regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia
GO:0071850	mitotic cell cycle arrest
GO:0072537	fibroblast activation
GO:0090272	negative regulation of fibroblast growth factor production
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization
GO:1901991	negative regulation of mitotic cell cycle phase transition
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022018

View Gene Order

ENSBTAG00000034885

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.507866

RefSeq

NM_014059

HUGO

OMIM

CCDS

CCDS41880

HPRD

17970

IMGT

EMBL

GenPept

RNA Seq Atlas