InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNPO1

Summary

InnateDB Protein

IDBP-27795.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNPO1

Protein Name

transportin 1

Synonyms

IPO2; KPNB2; MIP; MIP1; TRN;

Species

Homo sapiens

Ensembl Protein

ENSP00000336712

InnateDB Gene

IDBG-27793 (TNPO1)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner. {ECO:0000250, ECO:0000269PubMed:11682607, ECO:0000269PubMed:19124606, ECO:0000269PubMed:8986607, ECO:0000269PubMed:9687515}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	49 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0008536	Ran GTPase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006886	intracellular protein transport
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process