Version 5.4
Homo sapiens Gene: TNPO1
Summary
InnateDB Gene IDBG-27793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNPO1
Gene Name transportin 1
Synonyms IPO2; KPNB2; MIP; MIP1; TRN
Species Homo sapiens
Ensembl Gene ENSG00000083312
Encoded Proteins
IDBP-27795
transportin 1
IDBP-485397
transportin 1
IDBP-474343
transportin 1
IDBP-477143
transportin 1
IDBP-808248
transportin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:72816312-72916733
Strand Forward strand
Band q13.2
Transcripts
ENST00000337273 ENSP00000336712
ENST00000515483
ENST00000520850 ENSP00000430312
ENST00000523768 ENSP00000428899
ENST00000518279
ENST00000513944
ENST00000506351 ENSP00000425118
ENST00000509030
ENST00000511754
ENST00000506528
ENST00000508762
ENST00000505082
ENST00000503084
ENST00000605210 ENSP00000474059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 49 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008536 Ran GTPase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0006886 intracellular protein transport
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009470
View Gene Order
ENSBTAG00000007979
Not yet available
Pathways
NETPATH
REACTOME
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q92973
TrEMBL S4R398
UniProt Splice Variant
Entrez Gene 3842
UniGene Hs.100235 Hs.482497 Hs.605356 Hs.627274 Hs.640555
RefSeq NM_002270 NM_153188 XM_005248500
HUGO HGNC:6401
OMIM 602901
CCDS CCDS4016 CCDS43329
HPRD 04210
IMGT
EMBL AC008953 AC008972 AC035140 AK301021 BC040340 U70322 U72069 U72395
GenPept AAB58254 AAB68948 AAC50723 AAH40340 BAG62638
RNA Seq Atlas 3842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca