Version 5.4
Homo sapiens Protein: ASB4
Summary
InnateDB Protein IDBP-27818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB4
Protein Name ankyrin repeat and SOCS box containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000321388
InnateDB Gene IDBG-27816 (ASB4)
Protein Structure
UniProt Annotation
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0035556 intracellular signal transduction
GO:0051865 protein autoubiquitination
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF07525
PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00253
SM00969
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y574
PhosphoSite PhosphoSite-Q9Y574
TrEMBL
UniProt Splice Variant
Entrez Gene 51666
UniGene Hs.737518
RefSeq NP_057200
HUGO HGNC:16009
OMIM 605761
CCDS CCDS5641
HPRD 05770
IMGT
EMBL AC002451 AC003079 AF156779 BC025024 BC113479 BC113481 CH236949 CH471091
GenPept AAB83943 AAD41896 AAH25024 AAI13480 AAI13482 EAL24129 EAL24130 EAW76761 EAW76762

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca