Version 5.4
Homo sapiens Gene: ASB4
Summary
InnateDB Gene IDBG-27816.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB4
Gene Name ankyrin repeat and SOCS box containing 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000005981
Encoded Proteins
IDBP-27818
ankyrin repeat and SOCS box containing 4
IDBP-382298
ankyrin repeat and SOCS box containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:95478444-95540232
Strand Forward strand
Band q21.3
Transcripts
ENST00000325885 ENSP00000321388
ENST00000257621
ENST00000428113 ENSP00000397070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0035556 intracellular signal transduction
GO:0051865 protein autoubiquitination
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042607
View Gene Order
ENSBTAG00000018185
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.602765 Hs.737518
RefSeq NM_016116 NM_145872
HUGO
OMIM
CCDS CCDS5641 CCDS5642
HPRD 05770
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca