Version 5.4
Homo sapiens Protein: ALOXE3
Summary
InnateDB Protein IDBP-27884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOXE3
Protein Name arachidonate lipoxygenase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369494
InnateDB Gene IDBG-27882 (ALOXE3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0051120 hepoxilin A3 synthase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0019233 sensory perception of pain
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0043651 linoleic acid metabolic process
GO:0045444 fat cell differentiation
GO:0046513 ceramide biosynthetic process
GO:0051122 hepoxilin biosynthetic process
GO:0055114 oxidation-reduction process
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001024 PLAT/LH2 domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013819 Lipoxygenase, C-terminal
PFAM PF01477
PF00305
PRINTS PR00087
PIRSF
SMART SM00308
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL J3KPH2
UniProt Splice Variant
Entrez Gene 59344
UniGene Hs.232770
RefSeq XP_005256802
HUGO HGNC:13743
OMIM 607206
CCDS
HPRD 06231
IMGT
EMBL AC129492 AF182218 AJ269499 AJ305020 AJ305021 AJ305023 AJ305025 AK296416 AK313677 BC101938 BC101939 BC103508 BC104724 CH471108
GenPept AAG16899 AAI01939 AAI01940 AAI03509 AAI04725 BAG36428 BAH12346 CAC12843 CAC34518 EAW90093 EAW90094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca