InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALOXE3

Summary

InnateDB Gene

IDBG-27882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOXE3

Gene Name

arachidonate lipoxygenase 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000179148

Encoded Proteins

IDBP-27884

arachidonate lipoxygenase 3

IDBP-27886

arachidonate lipoxygenase 3

IDBP-367269

arachidonate lipoxygenase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8095900-8119047

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000380149	ENSP00000369494
ENST00000318227	ENSP00000314879
ENST00000448843	ENSP00000400581
ENST00000583808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding
GO:0051120	hepoxilin A3 synthase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0019233	sensory perception of pain
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0043651	linoleic acid metabolic process
GO:0045444	fat cell differentiation
GO:0046513	ceramide biosynthetic process
GO:0051122	hepoxilin biosynthetic process
GO:0055114	oxidation-reduction process
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020892

View Gene Order

ENSBTAG00000012478

Not yet available

Cross-References

SwissProt

Q9BYJ1

TrEMBL

UniProt Splice Variant

Entrez Gene

59344

UniGene

Hs.232770

RefSeq

NM_021628 NM_001165960 XM_005256745

HUGO

HGNC:13743

OMIM

607206

CCDS

CCDS11130 CCDS54084

HPRD

06231

IMGT

EMBL

AF182218 AJ269499 AJ305020 AJ305021 AJ305023 AJ305025 AK296416 AK313677 BC101938 BC101939 BC103508 BC104724 CH471108

GenPept

AAG16899 AAI01939 AAI01940 AAI03509 AAI04725 BAG36428 BAH12346 CAC12843 CAC34518 EAW90094

RNA Seq Atlas

59344