InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKX6-1

Summary

InnateDB Protein

IDBP-27906.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKX6-1

Protein Name

NK6 homeobox 1

Synonyms

NKX6.1; NKX6A;

Species

Homo sapiens

Ensembl Protein

ENSP00000295886

InnateDB Gene

IDBG-27904 (NKX6-1)

Protein Structure

UniProt Annotation

Function

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Pancreatic beta cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003323	type B pancreatic cell development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007224	smoothened signaling pathway
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0021953	central nervous system neuron differentiation
GO:0022008	neurogenesis
GO:0030154	cell differentiation
GO:0030516	regulation of axon extension
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0035094	response to nicotine
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0045686	negative regulation of glial cell differentiation
GO:0045687	positive regulation of glial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048709	oligodendrocyte differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051594	detection of glucose
GO:0071345	cellular response to cytokine stimulus
GO:0071375	cellular response to peptide hormone stimulus
GO:0072560	type B pancreatic cell maturation
GO:2000078	positive regulation of type B pancreatic cell development
GO:2001222	regulation of neuron migration