InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYNC1I1

Summary

InnateDB Protein

IDBP-27909.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNC1I1

Protein Name

dynein, cytoplasmic 1, intermediate chain 1

Synonyms

DNCI1; DNCIC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000352348

InnateDB Gene

IDBG-27907 (DYNC1I1)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Subcellular Localization

Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:19229290}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	80 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0030507	spectrin binding

Biological Process

GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0047496	vesicle transport along microtubule

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005829	cytosol
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0031982	vesicle
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0048471	perinuclear region of cytoplasm