InnateDB Protein
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IDBP-27968.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HES7
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Protein Name
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hairy and enhancer of split 7 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000314774
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InnateDB Gene
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IDBG-27966 (HES7)
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Protein Structure
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Function |
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Spondylocostal dysostosis 4, autosomal recessive (SCDO4) [MIM:613686]: A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations. {ECO:0000269PubMed:18775957, ECO:0000269PubMed:20087400}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003650
Orange
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF07527
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BYE0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84667
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UniGene |
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RefSeq |
NP_115969
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HUGO |
HGNC:15977
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OMIM |
608059
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CCDS |
CCDS42258
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HPRD |
09729
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IMGT |
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EMBL |
AB049064
AC129492
BC039887
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GenPept |
BAB39525
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