Homo sapiens Gene: HES7

Summary
InnateDB Gene IDBG-27966.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol HES7
Gene Name hairy and enhancer of split 7 (Drosophila)
Synonyms bHLHb37; SCDO4
Species Homo sapiens
Ensembl Gene ENSG00000179111
Encoded Proteins
IDBP-27968 hairy and enhancer of split 7 (Drosophila)
IDBP-594587 hairy and enhancer of split 7 (Drosophila)
IDBP-764713
Entrez Gene
Summary This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 8023908-8027410
Strand Reverse strand
Band p13.1
Transcripts
ENST00000317814  ENSP00000314774
ENST00000541682  ENSP00000446205
ENST00000577735  ENSP00000462491
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  1
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0008134 transcription factor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001756 somitogenesis
GO:0006351 transcription, DNA-dependent
GO:0006355 regulation of transcription, DNA-dependent
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0007498 mesoderm development
GO:0036342 post-anal tail morphogenesis
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0048511 rhythmic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000023781 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000012436 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
100146 Segmentation clock [Biocarta view]
PID NCI
Cross-References
SwissProt Q9BYE0 
TrEMBL F8VPC9 J3KSH6
UniProt Splice Variant
Entrez Gene 84667 
UniGene
RefSeq NM_001165967  NM_032580 
HUGO 15977 
OMIM 608059
CCDS CCDS42258  CCDS54085 
HPRD 09729
IMGT
EMBL AB049064 AC129492
GenPept BAB39525 
ImmGen HES7 (murine) 
RNA Seq Atlas 84667