Version 5.4
Homo sapiens Protein: SLC14A2
Summary
InnateDB Protein IDBP-2798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC14A2
Protein Name solute carrier family 14 (urea transporter), member 2
Synonyms hUT-A6; HUT2; UT-A2; UT2; UTA; UTR;
Species Homo sapiens
Ensembl Protein ENSP00000255226
InnateDB Gene IDBG-2796 (SLC14A2)
Protein Structure
UniProt Annotation
Function Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. {ECO:0000269PubMed:11502588, ECO:0000269PubMed:8647271}.
Subcellular Localization Apical cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. {ECO:0000269PubMed:11502588, ECO:0000269PubMed:8647271}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015204 urea transmembrane transporter activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0015840 urea transport
GO:0055085 transmembrane transport
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR004937 Urea transporter
PFAM PF03253
PRINTS
PIRSF PIRSF016502
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15849
PhosphoSite PhosphoSite-Q15849
TrEMBL
UniProt Splice Variant
Entrez Gene 8170
UniGene Hs.710927
RefSeq NP_009094
HUGO HGNC:10919
OMIM 601611
CCDS CCDS11924
HPRD 03366
IMGT
EMBL AC023421 AF349446 AK292422 BC110446 X96969
GenPept AAI10447 AAL08485 BAF85111 CAA65657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca