InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP13

Summary

InnateDB Protein

IDBP-28101.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP13

Protein Name

A kinase (PRKA) anchor protein 13

Synonyms

AKAP-13; AKAP-Lbc; ARHGEF13; BRX; c-lbc; HA-3; Ht31; LBC; p47; PRKA13; PROTO-LB; PROTO-LBC;

Species

Homo sapiens

Ensembl Protein

ENSP00000354718

InnateDB Gene

IDBG-28095 (AKAP13)

Protein Structure

UniProt Annotation

Function

Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. {ECO:0000269PubMed:11546812, ECO:0000269PubMed:11579095, ECO:0000269PubMed:9627117, ECO:0000269PubMed:9891067}.

Subcellular Localization

Cytoplasm. Nucleus. Membrane.

Disease Associations

Tissue Specificity

Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen- responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269PubMed:11546812, ECO:0000269PubMed:9627117, ECO:0000269PubMed:9891067}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	27 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004691	cAMP-dependent protein kinase activity
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0032947	protein complex scaffold
GO:0046872	metal ion binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007264	small GTPase mediated signal transduction
GO:0010611	regulation of cardiac muscle hypertrophy
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0045859	regulation of protein kinase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051168	nuclear export
GO:0097190	apoptotic signaling pathway
GO:1900169	regulation of glucocorticoid mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00621
PF00169
PF00130
PF11929
PF12796

PRINTS

PIRSF

SMART

SM00325
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q12802