InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAC1

Summary

InnateDB Protein

IDBP-28147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAC1

Protein Name

tachykinin, precursor 1

Synonyms

Hs.2563; NK2; NKNA; NPK; TAC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000321106

InnateDB Gene

IDBG-28145 (TAC1)

Protein Structure

UniProt Annotation

Function

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031835	substance P receptor binding

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0006954	inflammatory response
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007217	tachykinin receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0007320	insemination
GO:0007616	long-term memory
GO:0008217	regulation of blood pressure
GO:0008306	associative learning
GO:0009582	detection of abiotic stimulus
GO:0009725	response to hormone
GO:0010459	negative regulation of heart rate
GO:0010634	positive regulation of epithelial cell migration
GO:0019233	sensory perception of pain
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0035815	positive regulation of renal sodium excretion
GO:0043278	response to morphine
GO:0045760	positive regulation of action potential
GO:0045778	positive regulation of ossification
GO:0046878	positive regulation of saliva secretion
GO:0048265	response to pain
GO:0050671	positive regulation of lymphocyte proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:2000854	positive regulation of corticosterone secretion