Version 5.4
Homo sapiens Protein: TAC1
Summary
InnateDB Protein IDBP-28151.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAC1
Protein Name tachykinin, precursor 1
Synonyms Hs.2563; NK2; NKNA; NPK; TAC2;
Species Homo sapiens
Ensembl Protein ENSP00000289576
InnateDB Gene IDBG-28145 (TAC1)
Protein Structure
UniProt Annotation
Function Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007217 tachykinin receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0007320 insemination
GO:0009582 detection of abiotic stimulus
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR008216 Protachykinin
PFAM
PRINTS PR01829
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20366
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 6863
UniGene Hs.601895
RefSeq NP_054704
HUGO HGNC:11517
OMIM 162320
CCDS CCDS5650
HPRD 08876
IMGT
EMBL AC004140 AF050655 AF050656 AF050658 AK222957 BC018047 CH236949 CH471091 CR407602 CR541730 M68906 M68907 U37529 X54469
GenPept AAA60159 AAA60160 AAA79195 AAC15701 AAC15702 AAC15704 AAH18047 AAQ96888 AAQ96889 AAQ96890 AAQ96891 BAD96677 CAA38351 CAG28529 CAG46531 EAL24116 EAL24117 EAL24118 EAL24119 EAW76734 EAW76735 EAW76736 EAW76737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca