InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP8B1

Summary

InnateDB Protein

IDBP-28187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP8B1

Protein Name

cytochrome P450, family 8, subfamily B, polypeptide 1

Synonyms

CP8B; CYP12;

Species

Homo sapiens

Ensembl Protein

ENSP00000318867

InnateDB Gene

IDBG-28185 (CYP8B1)

Protein Structure

UniProt Annotation

Function

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008397	sterol 12-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0033778	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006699	bile acid biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process