InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP8B1

Summary

InnateDB Gene

IDBG-28185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP8B1

Gene Name

cytochrome P450, family 8, subfamily B, polypeptide 1

Synonyms

CP8B; CYP12

Species

Homo sapiens

Ensembl Gene

ENSG00000180432

Encoded Proteins

IDBP-28187

cytochrome P450, family 8, subfamily B, polypeptide 1

IDBP-373737

cytochrome P450, family 8, subfamily B, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:42856005-42876165

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000316161	ENSP00000318867
ENST00000437102	ENSP00000404499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008397	sterol 12-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0033778	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006699	bile acid biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000050445

View Gene Order

Pathways

NETPATH

REACTOME

REACT_11053

Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway

REACT_11041

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway

REACT_11048

Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway

REACT_11054

Synthesis of bile acids and bile salts pathway

REACT_150149

Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_11213

Nicotinamide salvaging pathway

REACT_11088

Nicotinate metabolism pathway

REACT_13438

Sterols are 12-hydroxylated by CYP8B1 pathway

REACT_13812

Endogenous sterols pathway

REACT_13645

Eicosanoids pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_169312

Defective HLCS causes multiple carboxylase deficiency pathway

REACT_169313

Defective MUT causes methylmalonic aciduria mut type pathway

REACT_169316

Defective MMAA causes methylmalonic aciduria type cblA pathway

REACT_169120

Defective TCN2 causes hereditary megaloblastic anemia pathway

REACT_11040

Bile acid and bile salt metabolism pathway

REACT_11238

Metabolism of water-soluble vitamins and cofactors pathway

REACT_169280

Defective AMN causes hereditary megaloblastic anemia 1 pathway

REACT_169149

Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway

REACT_169363

Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway

REACT_169178

Defective CD320 causes methylmalonic aciduria pathway

REACT_169429

Defects in cobalamin (B12) metabolism pathway

REACT_169169

Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway

REACT_169238

Defects in biotin (Btn) metabolism pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_169403

Defective BTD causes biotidinase deficiency pathway

REACT_169415

Defective GIF causes intrinsic factor deficiency pathway

REACT_169385

Defects in vitamin and cofactor metabolism pathway

REACT_169132

Defective CUBN causes hereditary megaloblastic anemia 1 pathway

REACT_169256

Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway

REACT_169439

Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway

REACT_111217

Metabolism pathway

REACT_169318

Defective MMAB causes methylmalonic aciduria type cblB pathway

REACT_13433

Biological oxidations pathway

REACT_116125

Disease pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

REACT_11193

Metabolism of vitamins and cofactors pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa00120

Primary bile acid biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.447793 Hs.722743

RefSeq

NM_004391

HUGO

OMIM

CCDS

CCDS2707

HPRD

03705

IMGT

EMBL

GenPept

RNA Seq Atlas