InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RRM2

Summary

InnateDB Protein

IDBP-28302.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM2

Protein Name

ribonucleotide reductase M2

Synonyms

R2; RR2; RR2M;

Species

Homo sapiens

Ensembl Protein

ENSP00000353770

InnateDB Gene

IDBG-28300 (RRM2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009262	deoxyribonucleotide metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process