InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RRM2

Summary

InnateDB Gene

IDBG-28300.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM2

Gene Name

ribonucleotide reductase M2

Synonyms

R2; RR2; RR2M

Species

Homo sapiens

Ensembl Gene

ENSG00000171848

Encoded Proteins

IDBP-28302

ribonucleotide reductase M2

IDBP-28304

ribonucleotide reductase M2

IDBP-481111

ribonucleotide reductase M2

IDBP-810407

ribonucleotide reductase M2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:10122328-10131419

Strand

Forward strand

Band

p25.1

Transcripts

ENST00000360566	ENSP00000353770
ENST00000304567	ENSP00000302955
ENST00000459969
ENST00000461327
ENST00000498343
ENST00000491447
ENST00000474701	ENSP00000419177
ENST00000487591
ENST00000462343
ENST00000485717
ENST00000615152	ENSP00000484183

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009262	deoxyribonucleotide metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process