InnateDB Protein
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IDBP-28315.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC26A7
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Protein Name
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solute carrier family 26, member 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000276609
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InnateDB Gene
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IDBG-28311 (SLC26A7)
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Protein Structure
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Function |
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. {ECO:0000250UniProtKB:Q8R2Z3, ECO:0000269PubMed:11834742, ECO:0000269PubMed:12736153}.
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Subcellular Localization |
Recycling endosome membrane {ECO:0000269PubMed:16524946}; Multi-pass membrane protein {ECO:0000269PubMed:16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269PubMed:16524946}.
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Disease Associations |
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Tissue Specificity |
Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. {ECO:0000269PubMed:11829495, ECO:0000269PubMed:11834742, ECO:0000269PubMed:15956810, ECO:0000269PubMed:17504921}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005254
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chloride channel activity
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GO:0015106
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bicarbonate transmembrane transporter activity
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GO:0015116
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sulfate transmembrane transporter activity
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GO:0015301
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anion:anion antiporter activity
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GO:0019531
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oxalate transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002645
STAS domain
IPR011547
Sulphate transporter
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PFAM |
PF01740
PF13466
PF00916
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TE54
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PhosphoSite |
PhosphoSite-Q8TE54
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TrEMBL |
E5RFH2
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UniProt Splice Variant |
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Entrez Gene |
115111
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UniGene |
Hs.354013
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RefSeq |
NP_439897
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HUGO |
HGNC:14467
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OMIM |
608479
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CCDS |
CCDS6254
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HPRD |
10533
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IMGT |
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EMBL |
AC087847
AC104966
AC104967
AF331521
AJ413228
AJ413229
AJ413230
BC094730
BC113866
BC114474
CH471060
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GenPept |
AAH94730
AAI13867
AAI14475
AAK95665
CAC88370
CAC88371
CAC88372
EAW91679
EAW91680
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