InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANO6

Summary

InnateDB Protein

IDBP-28320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANO6

Protein Name

anoctamin 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320087

InnateDB Gene

IDBG-28318 (ANO6)

Protein Structure

UniProt Annotation

Function

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO:0000269PubMed:20056604, ECO:0000269PubMed:21107324, ECO:0000269PubMed:21908539, ECO:0000269PubMed:22006324, ECO:0000269PubMed:22946059}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20056604, ECO:0000269PubMed:21107324, ECO:0000269PubMed:22075693, ECO:0000269PubMed:22946059}; Multi-pass membrane protein {ECO:0000269PubMed:20056604, ECO:0000269PubMed:21107324, ECO:0000269PubMed:22075693, ECO:0000269PubMed:22946059}. Note=Shows an intracellular localization according to PubMed:22075693.

Disease Associations

Scott syndrome (SCTS) [MIM:262890]: A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. {ECO:0000269PubMed:21107324}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. {ECO:0000269PubMed:15067359}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005227	calcium activated cation channel activity
GO:0005229	intracellular calcium activated chloride channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005247	voltage-gated chloride channel activity

Biological Process

GO:0002543	activation of blood coagulation via clotting cascade
GO:0006812	cation transport
GO:0006821	chloride transport
GO:0007596	blood coagulation
GO:0017121	phospholipid scrambling
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0045087	innate immune response (InnateDB)
GO:0055085	transmembrane transport
GO:0097045	phosphatidylserine exposure on blood platelet
GO:1902476	chloride transmembrane transport
GO:2000353	positive regulation of endothelial cell apoptotic process