Version 5.4
Homo sapiens Gene: ANO6
Summary
InnateDB Gene IDBG-28318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO6
Gene Name anoctamin 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177119
Encoded Proteins
IDBP-28320
anoctamin 6
IDBP-372888
anoctamin 6
IDBP-372895
anoctamin 6
IDBP-372899
anoctamin 6
IDBP-599290
anoctamin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25651887
Stimulation of P2RX7 receptors activates ANO6 to enhance bacterial phagocytosis and killing by macrophages.
Entrez Gene
Summary This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:45215987-45440404
Strand Forward strand
Band q12
Transcripts
ENST00000320560 ENSP00000320087
ENST00000425752 ENSP00000391417
ENST00000426898
ENST00000423947 ENSP00000409126
ENST00000441606 ENSP00000413137
ENST00000550630 ENSP00000449423
ENST00000551667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005227 calcium activated cation channel activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0017128 phospholipid scramblase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0002543 activation of blood coagulation via clotting cascade
GO:0006812 cation transport
GO:0006821 chloride transport
GO:0007596 blood coagulation
GO:0017121 phospholipid scrambling
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035630 bone mineralization involved in bone maturation
GO:0044070 regulation of anion transport
GO:0045087 innate immune response (InnateDB)
GO:0055085 transmembrane transport
GO:0061588 calcium activated phospholipid scrambling
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:0097045 phosphatidylserine exposure on blood platelet
GO:1902476 chloride transmembrane transport
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064210
View Gene Order
ENSBTAG00000002902
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q4KMQ2
TrEMBL
UniProt Splice Variant
Entrez Gene 196527
UniGene Hs.505339
RefSeq NM_001025356 XM_005268707 NM_001142678 NM_001142679 NM_001204803 XM_005268706 XM_006719271
HUGO HGNC:25240
OMIM 608663
CCDS CCDS31782 CCDS44865 CCDS44866 CCDS55819
HPRD 18746
IMGT
EMBL AC009248 AC009778 AC063924 AL833405 BC098410 BC136445
GenPept AAH98410 AAI36446 CAD38638
RNA Seq Atlas 196527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca