InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RUNX1T1

Summary

InnateDB Protein

IDBP-28424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUNX1T1

Protein Name

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Synonyms

AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2;

Species

Homo sapiens

Ensembl Protein

ENSP00000265814

InnateDB Gene

IDBG-28420 (RUNX1T1)

Protein Structure

UniProt Annotation

Function

Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. {ECO:0000269PubMed:10973986, ECO:0000269PubMed:16803958}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00440, ECO:0000269PubMed:10973986}. Note=Colocalizes with ATN1 in discrete nuclear dots.

Disease Associations

Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	67 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0016363

nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002893 Zinc finger, MYND-type
IPR003894 TAFH/NHR1
IPR013289 Eight-Twenty-One
IPR013290 Myeloid transforming gene on chromosome 8 (MTG8)
IPR014896 NHR2-like

PFAM

PF01753
PF07531
PF08788

PRINTS

PR01875
PR01876

PIRSF

SMART

SM00549

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt