Version 5.4
Homo sapiens Gene: RUNX1T1
Summary
InnateDB Gene IDBG-28420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUNX1T1
Gene Name runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Synonyms AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
Species Homo sapiens
Ensembl Gene ENSG00000079102
Encoded Proteins
IDBP-28422
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-28424
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-237959
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-373427
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-373444
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-476868
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478671
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478611
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-474437
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478835
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-476896
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-481068
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-482722
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-473440
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-479243
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-477845
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-476203
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-483802
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-473906
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-482131
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-479616
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-484172
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-484081
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478446
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-480173
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-482018
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-482287
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-479287
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-483558
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478763
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-480384
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-475810
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478943
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-480638
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-481193
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-478905
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-810062
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-810063
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-810064
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-810065
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-810066
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5\'-region of the runt-related transcription factor 1 gene fused to the 3\'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:91954967-92103286
Strand Reverse strand
Band q21.3
Transcripts
ENST00000360348 ENSP00000353504
ENST00000265814 ENSP00000265814
ENST00000396218 ENSP00000379520
ENST00000422361 ENSP00000390137
ENST00000436581 ENSP00000402257
ENST00000523629 ENSP00000428543
ENST00000520724 ENSP00000428742
ENST00000521078
ENST00000518844 ENSP00000430728
ENST00000521751 ENSP00000430778
ENST00000520978 ENSP00000429085
ENST00000518361 ENSP00000430863
ENST00000520047
ENST00000521553 ENSP00000429728
ENST00000522316
ENST00000518992 ENSP00000431094
ENST00000521054 ENSP00000427763
ENST00000523290
ENST00000519847 ENSP00000430204
ENST00000517792 ENSP00000429940
ENST00000522467 ENSP00000429532
ENST00000517919 ENSP00000429506
ENST00000521733 ENSP00000430637
ENST00000520556 ENSP00000428100
ENST00000521319 ENSP00000429137
ENST00000520583 ENSP00000430070
ENST00000523168 ENSP00000429118
ENST00000519577 ENSP00000430084
ENST00000518823 ENSP00000428475
ENST00000521897 ENSP00000429653
ENST00000518317 ENSP00000429062
ENST00000521375 ENSP00000429666
ENST00000519422 ENSP00000429587
ENST00000524215 ENSP00000429034
ENST00000520974 ENSP00000429375
ENST00000518832 ENSP00000429864
ENST00000520172
ENST00000517493
ENST00000522065
ENST00000518954 ENSP00000430080
ENST00000519061 ENSP00000430334
ENST00000518256
ENST00000520428 ENSP00000429857
ENST00000522163
ENST00000521902
ENST00000522860
ENST00000518449 ENSP00000428133
ENST00000614812 ENSP00000481315
ENST00000615601 ENSP00000480500
ENST00000617740 ENSP00000481112
ENST00000613886 ENSP00000478331
ENST00000613302 ENSP00000481799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 67 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045444 fat cell differentiation
GO:0051101 regulation of DNA binding
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006586
View Gene Order
ENSBTAG00000017339
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt Q06455
TrEMBL E5RFQ3 E5RG85 E5RH30 E5RH72 E5RHJ8 E5RI38 E5RJ32 E5RJB3 E5RJE7 E5RK76 Q9HBV9 W8FW32
UniProt Splice Variant
Entrez Gene 862
UniGene Hs.368431 Hs.594620 Hs.624033 Hs.626145 Hs.739194
RefSeq NM_004349 NM_001198625 NM_001198626 NM_001198627 NM_001198628 NM_001198629 NM_001198630 NM_001198631 NM_001198632 NM_001198633 NM_001198634 NM_001198679 NM_175634 NM_175635 NM_175636 XM_006716676
HUGO HGNC:1535
OMIM 133435
CCDS CCDS47891 CCDS56544 CCDS6256 CCDS6257 CCDS75766 CCDS75767
HPRD 00590
IMGT
EMBL AC103680 AC104339 AF018270 AF018271 AF018272 AF018273 AF018274 AF018275 AF018276 AF018277 AF018278 AF018279 AF018281 AF018282 AF018283 AF181450 AF198490 AK297616 BC005850 BC067078 BT009871 CH471060 CR456792 D13979 D14289 D14821 D14822 D14823 D43638 KF946514 KF946518 S50186 S74092 S74096 S78158 S78159 X79990
GenPept AAB32126 AAB34819 AAB34820 AAC26143 AAC28931 AAC28932 AAG33024 AAH05850 AAH67078 AAP88873 AHK05730 AHK05734 BAA03089 BAA03247 BAA03558 BAA03559 BAA03560 BAA07755 BAH12630 CAA56311 CAG33073 EAW91685
RNA Seq Atlas 862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca