InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMED1

Summary

InnateDB Protein

IDBP-28441.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMED1

Protein Name

transmembrane emp24 protein transport domain containing 1

Synonyms

Il1rl1l; IL1RL1LG; Tp24;

Species

Homo sapiens

Ensembl Protein

ENSP00000214869

InnateDB Gene

IDBG-28439 (TMED1)

Protein Structure

UniProt Annotation

Function

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:8621446}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0015031	protein transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane