Version 5.4
Homo sapiens Gene: TMED1
Summary
InnateDB Gene IDBG-28439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMED1
Gene Name transmembrane emp24 protein transport domain containing 1
Synonyms Il1rl1l; IL1RL1LG; Tp24
Species Homo sapiens
Ensembl Gene ENSG00000099203
Encoded Proteins
IDBP-28441
transmembrane emp24 protein transport domain containing 1
IDBP-762327
IDBP-763364
IDBP-765801
IDBP-764643
IDBP-760240
IDBP-761655
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1). This protein lacks any similarity to other interleukin 1 ligands. The functional significance of its interaction with IL1RL1 is not known. [provided by RefSeq, Jul 2008]
This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10832438-10836318
Strand Reverse strand
Band p13.2
Transcripts
ENST00000214869 ENSP00000214869
ENST00000586835 ENSP00000464856
ENST00000588289 ENSP00000464824
ENST00000591695 ENSP00000468294
ENST00000591157 ENSP00000468492
ENST00000589638 ENSP00000467690
ENST00000588259 ENSP00000468054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0015031 protein transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032180
View Gene Order
ENSBTAG00000010968
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515139
RefSeq NM_006858 XM_006722631
HUGO
OMIM
CCDS CCDS12249
HPRD 05653
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca