InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFAS

Summary

InnateDB Protein

IDBP-28489.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFAS

Protein Name

phosphoribosylformylglycinamidine synthase

Synonyms

FGAMS; FGAR-AT; FGARAT; PURL;

Species

Homo sapiens

Ensembl Protein

ENSP00000313490

InnateDB Gene

IDBG-28485 (PFAS)

Protein Structure

UniProt Annotation

Function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004642	phosphoribosylformylglycinamidine synthase activity
GO:0005524	ATP binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000728 AIR synthase related protein, N-terminal domain
IPR010073 Phosphoribosylformylglycinamidine synthase
IPR010918 AIR synthase-related protein, C-terminal domain
IPR016188 PurM, N-terminal-like
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF00586
PF02769

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15067

PhosphoSite