Version 5.4
Homo sapiens Gene: PFAS
Summary
InnateDB Gene IDBG-28485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFAS
Gene Name phosphoribosylformylglycinamidine synthase
Synonyms FGAMS; FGAR-AT; FGARAT; PURL
Species Homo sapiens
Ensembl Gene ENSG00000178921
Encoded Proteins
IDBP-28489
phosphoribosylformylglycinamidine synthase
IDBP-603650
phosphoribosylformylglycinamidine synthase
IDBP-762402
IDBP-762882
IDBP-760182
IDBP-758719
IDBP-760484
IDBP-763412
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8247618-8270491
Strand Forward strand
Band p13.1
Transcripts
ENST00000314666 ENSP00000313490
ENST00000546020 ENSP00000443244
ENST00000580251
ENST00000585319
ENST00000580356 ENSP00000464671
ENST00000585183 ENSP00000463362
ENST00000583059 ENSP00000462874
ENST00000584044 ENSP00000464689
ENST00000578979 ENSP00000463103
ENST00000581288
ENST00000581242 ENSP00000463045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020899
View Gene Order
ENSBTAG00000031509
Not yet available
Pathways
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.573976 Hs.623475
RefSeq NM_012393 XM_006721546
HUGO
OMIM
CCDS CCDS11136
HPRD 09072
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca