InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP14

Summary

InnateDB Protein

IDBP-2850.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP14

Protein Name

matrix metallopeptidase 14 (membrane-inserted)

Synonyms

MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000308208

InnateDB Gene

IDBG-2848 (MMP14)

Protein Structure

UniProt Annotation

Function

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. {ECO:0000269PubMed:12714657, ECO:0000269PubMed:20837484, ECO:0000269PubMed:22065321}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Disease Associations

Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269PubMed:18223680}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016504	peptidase activator activity

Biological Process

GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001541	ovarian follicle development
GO:0001666	response to hypoxia
GO:0001935	endothelial cell proliferation
GO:0001958	endochondral ossification
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0006979	response to oxidative stress
GO:0008584	male gonad development
GO:0009612	response to mechanical stimulus
GO:0009725	response to hormone
GO:0010952	positive regulation of peptidase activity
GO:0014070	response to organic cyclic compound
GO:0016477	cell migration
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030307	positive regulation of cell growth
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0030574	collagen catabolic process
GO:0031638	zymogen activation
GO:0035988	chondrocyte proliferation
GO:0043615	astrocyte cell migration
GO:0043627	response to estrogen
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048771	tissue remodeling
GO:0051895	negative regulation of focal adhesion assembly
GO:0060348	bone development
GO:0097094	craniofacial suture morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal

PFAM

PF00413
PF01471
PF00045
PF11857

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References