InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RANGRF

Summary

InnateDB Protein

IDBP-28645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RANGRF

Protein Name

RAN guanine nucleotide release factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000226105

InnateDB Gene

IDBG-28643 (RANGRF)

Protein Structure

UniProt Annotation

Function

May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A. {ECO:0000269PubMed:11290418, ECO:0000269PubMed:18184654}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11290418}. Cytoplasm {ECO:0000269PubMed:11290418}. Note=Shuttles between the nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are ubiquitously expressed. {ECO:0000269PubMed:11290418}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding

Biological Process

GO:0002027	regulation of heart rate
GO:0003254	regulation of membrane depolarization
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0032527	protein exit from endoplasmic reticulum
GO:0042391	regulation of membrane potential
GO:0043547	positive regulation of GTPase activity
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential
GO:1902305	regulation of sodium ion transmembrane transport
GO:2000010	positive regulation of protein localization to cell surface
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0014704	intercalated disc