Version 5.4
Homo sapiens Gene: RANGRF
Summary
InnateDB Gene IDBG-28643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RANGRF
Gene Name RAN guanine nucleotide release factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108961
Encoded Proteins
IDBP-28645
RAN guanine nucleotide release factor
IDBP-294434
RAN guanine nucleotide release factor
IDBP-367601
RAN guanine nucleotide release factor
IDBP-762424
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8288497-8290092
Strand Forward strand
Band p13.1
Transcripts
ENST00000226105 ENSP00000226105
ENST00000407006 ENSP00000383940
ENST00000439238 ENSP00000413190
ENST00000580777
ENST00000578849
ENST00000580434 ENSP00000462310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
Biological Process
GO:0002027 regulation of heart rate
GO:0003254 regulation of membrane depolarization
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0032527 protein exit from endoplasmic reticulum
GO:0042391 regulation of membrane potential
GO:0043547 positive regulation of GTPase activity
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential
GO:1902305 regulation of sodium ion transmembrane transport
GO:2000010 positive regulation of protein localization to cell surface
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0014704 intercalated disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032892
View Gene Order
ENSBTAG00000018809
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.408233
RefSeq NM_001177801 NM_001177802 NM_016492 XM_005256618
HUGO
OMIM
CCDS CCDS11137 CCDS54086 CCDS54087
HPRD 06407
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca