InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ODC1

Summary

InnateDB Protein

IDBP-28664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODC1

Protein Name

ornithine decarboxylase 1

Synonyms

ODC;

Species

Homo sapiens

Ensembl Protein

ENSP00000234111

InnateDB Gene

IDBG-28660 (ODC1)

Protein Structure

UniProt Annotation

Function

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. {ECO:0000269PubMed:17900240}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004586	ornithine decarboxylase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001822	kidney development
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0008284	positive regulation of cell proliferation
GO:0009615	response to virus
GO:0033387	putrescine biosynthetic process from ornithine
GO:0034641	cellular nitrogen compound metabolic process
GO:0042176	regulation of protein catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000183 Ornithine/DAP/Arg decarboxylase
IPR002433 Ornithine decarboxylase
IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
IPR029066 PLP-binding barrel

PFAM

PF00278
PF02784

PRINTS

PR01179
PR01182

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11926