InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ODC1

Summary

InnateDB Gene

IDBG-28660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODC1

Gene Name

ornithine decarboxylase 1

Synonyms

ODC

Species

Homo sapiens

Ensembl Gene

ENSG00000115758

Encoded Proteins

IDBP-28664

ornithine decarboxylase 1

IDBP-292762

ornithine decarboxylase 1

IDBP-363418

ornithine decarboxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:10439968-10448504

Strand

Reverse strand

Band

p25.1

Transcripts

ENST00000234111	ENSP00000234111
ENST00000405333	ENSP00000385333
ENST00000446285
ENST00000443218	ENSP00000390691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004586	ornithine decarboxylase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001822	kidney development
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0008284	positive regulation of cell proliferation
GO:0009615	response to virus
GO:0033387	putrescine biosynthetic process from ornithine
GO:0034641	cellular nitrogen compound metabolic process
GO:0042176	regulation of protein catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000011179

View Gene Order

ENSBTAG00000004256

Not yet available

Pathways

NETPATH

REACTOME

REACT_14820

Metabolism of polyamines pathway

REACT_13565

Regulation of ornithine decarboxylase (ODC) pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

hsa00480

Glutathione metabolism pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.467701 Hs.678417

RefSeq

NM_001287188 NM_001287189 NM_001287190 NM_002539

HUGO

OMIM

CCDS

CCDS1672

HPRD

01324

IMGT

EMBL

GenPept

RNA Seq Atlas