InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRRAP

Summary

InnateDB Protein

IDBP-28700.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRRAP

Protein Name

transformation/transcription domain-associated protein

Synonyms

PAF350/400; PAF400; STAF40; TR-AP; Tra1;

Species

Homo sapiens

Ensembl Protein

ENSP00000347733

InnateDB Gene

IDBG-28698 (TRRAP)

Protein Structure

UniProt Annotation

Function

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269PubMed:11418595, ECO:0000269PubMed:12138177, ECO:0000269PubMed:12660246, ECO:0000269PubMed:12743606, ECO:0000269PubMed:14966270, ECO:0000269PubMed:17967892, ECO:0000269PubMed:24463511, ECO:0000269PubMed:9708738}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11564863, ECO:0000269PubMed:9708738}.

Disease Associations

Note=TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAP may play a role in the pathogenesis of melanoma. {ECO:0000269PubMed:21499247}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	104 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0016573	histone acetylation
GO:0016578	histone deubiquitination
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000125	PCAF complex
GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0035267	NuA4 histone acetyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR011009 Protein kinase-like domain
IPR014009 PIK-related kinase
IPR016024 Armadillo-type fold

PFAM

PF00454
PF02259
PF02260

PRINTS

PIRSF

SMART

SM00146

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y4A5