InnateDB Protein
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IDBP-28712.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGEF15
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Protein Name
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Rho guanine nucleotide exchange factor (GEF) 15
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Synonyms
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ARGEF15; E5; Ephexin5; Vsm-RhoGEF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355026
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InnateDB Gene
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IDBG-28708 (ARHGEF15)
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Protein Structure
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Function |
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269PubMed:12775584}.
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Subcellular Localization |
Cell projection, dendrite {ECO:0000250}. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the vascular smooth muscle of coronary artery. {ECO:0000269PubMed:12775584}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0032321
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positive regulation of Rho GTPase activity
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GO:0035023
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regulation of Rho protein signal transduction
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GO:0050790
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regulation of catalytic activity
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GO:0061299
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retina vasculature morphogenesis in camera-type eye
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GO:2000297
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negative regulation of synapse maturation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000219
Dbl homology (DH) domain
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PFAM |
PF00621
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PRINTS |
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PIRSF |
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SMART |
SM00325
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TIGRFAMs |
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Modification |
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SwissProt |
O94989
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PhosphoSite |
PhosphoSite-O94989
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TrEMBL |
J3QS60
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UniProt Splice Variant |
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Entrez Gene |
22899
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UniGene |
Hs.443109
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RefSeq |
NP_776089
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HUGO |
HGNC:15590
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OMIM |
608504
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CCDS |
CCDS11139
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HPRD |
10535
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IMGT |
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EMBL |
AB020722
AC135178
AK291626
BC036749
CH471108
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GenPept |
AAH36749
BAA74938
BAF84315
EAW90060
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