InnateDB Protein
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IDBP-28715.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ISG20
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Protein Name
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interferon stimulated exonuclease gene 20kDa
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Synonyms
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CD25; HEM45;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306565
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InnateDB Gene
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IDBG-28713 (ISG20)
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Protein Structure
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Function |
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269PubMed:11401564, ECO:0000269PubMed:12594219, ECO:0000269PubMed:16033969, ECO:0000269PubMed:21036379}.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
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Disease Associations |
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Tissue Specificity |
Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. {ECO:0000269PubMed:9235947, ECO:0000269PubMed:9569007}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006055
Exonuclease
IPR012337
Ribonuclease H-like domain
IPR013520
Exonuclease, RNase T/DNA polymerase III
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PFAM |
PF00929
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PRINTS |
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PIRSF |
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SMART |
SM00479
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TIGRFAMs |
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Modification |
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SwissProt |
Q96AZ6
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PhosphoSite |
PhosphoSite-Q96AZ6
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TrEMBL |
A0A024RC76
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UniProt Splice Variant |
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Entrez Gene |
3669
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UniGene |
Hs.459265
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RefSeq |
NP_002192
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HUGO |
HGNC:6130
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OMIM |
604533
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CCDS |
CCDS10345
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HPRD |
05169
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IMGT |
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EMBL |
BC007922
BC016341
BT006952
CH471101
CR456942
U88964
X89773
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GenPept |
AAB53416
AAH07922
AAH16341
AAP35598
CAA61915
CAG33223
EAX02013
EAX02014
EAX02016
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