InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ISG20

Summary

InnateDB Gene

IDBG-28713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ISG20

Gene Name

interferon stimulated exonuclease gene 20kDa

Synonyms

CD25; HEM45

Species

Homo sapiens

Ensembl Gene

ENSG00000172183

Encoded Proteins

IDBP-28715

interferon stimulated exonuclease gene 20kDa

IDBP-28717

interferon stimulated exonuclease gene 20kDa

IDBP-604146

interferon stimulated exonuclease gene 20kDa

IDBP-604147

interferon stimulated exonuclease gene 20kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15064795

ISG20 is an IFN-induced 3'-5' exonuclease that is strongly induced by viral double stranded RNA and is activated by RELA/NFKB1.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:88636153-88656483

Strand

Forward strand

Band

q26.1

Transcripts

ENST00000306072	ENSP00000306565
ENST00000379224	ENSP00000368526
ENST00000560741	ENSP00000453638
ENST00000558992
ENST00000559876	ENSP00000453666
ENST00000558942
ENST00000560573
ENST00000557824
ENST00000558236
ENST00000560746
ENST00000546338

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008859	exoribonuclease II activity
GO:0030619	U1 snRNA binding
GO:0030620	U2 snRNA binding
GO:0034511	U3 snoRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006364	rRNA processing
GO:0006401	RNA catabolic process
GO:0008283	cell proliferation
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016605	PML body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039236

View Gene Order

ENSBTAG00000014762

Not yet available

Pathways

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.459265

RefSeq

NM_002201 XM_006720489 XM_006720490

HUGO

OMIM

CCDS

CCDS10345

HPRD

05169

IMGT

EMBL

GenPept

RNA Seq Atlas