InnateDB Protein
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IDBP-28804.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDH17
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Protein Name
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cadherin 17, LI cadherin (liver-intestine)
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Synonyms
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CDH16; HPT-1; HPT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000027335
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InnateDB Gene
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IDBG-28802 (CDH17)
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Protein Structure
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Function |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269PubMed:8153632}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. {ECO:0000269PubMed:8153632}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0005215
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transporter activity
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GO:0005427
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proton-dependent oligopeptide secondary active transmembrane transporter activity
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GO:0005509
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calcium ion binding
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002126
Cadherin
IPR015919
Cadherin-like
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PFAM |
PF00028
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PRINTS |
PR00205
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PIRSF |
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SMART |
SM00112
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TIGRFAMs |
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Modification |
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SwissProt |
Q12864
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PhosphoSite |
PhosphoSite-Q12864
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TrEMBL |
E5RJT3
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UniProt Splice Variant |
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Entrez Gene |
1015
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UniGene |
Hs.89436
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RefSeq |
NP_004054
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HUGO |
HGNC:1756
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OMIM |
603017
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CCDS |
CCDS6260
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HPRD |
04312
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IMGT |
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EMBL |
AP003351
AP003478
BC112013
BC113464
U07969
X83228
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GenPept |
AAA19021
AAI12014
AAI13465
CAA58231
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