Version 5.4
Homo sapiens Gene: CDH17
Summary
InnateDB Gene IDBG-28802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH17
Gene Name cadherin 17, LI cadherin (liver-intestine)
Synonyms CDH16; HPT-1; HPT1
Species Homo sapiens
Ensembl Gene ENSG00000079112
Encoded Proteins
IDBP-28804
cadherin 17, LI cadherin (liver-intestine)
IDBP-373699
cadherin 17, LI cadherin (liver-intestine)
IDBP-373703
cadherin 17, LI cadherin (liver-intestine)
IDBP-475226
cadherin 17, LI cadherin (liver-intestine)
IDBP-475641
cadherin 17, LI cadherin (liver-intestine)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94127171-94217303
Strand Reverse strand
Band q22.1
Transcripts
ENST00000027335 ENSP00000027335
ENST00000450165 ENSP00000401468
ENST00000441892 ENSP00000392811
ENST00000520952 ENSP00000429730
ENST00000521491 ENSP00000428189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006857 oligopeptide transport
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
GO:0035672 oligopeptide transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028217
View Gene Order
ENSBTAG00000021964
Not yet available
Pathways
NETPATH
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591853 Hs.89436
RefSeq NM_001144663 NM_004063
HUGO
OMIM
CCDS CCDS6260
HPRD 04312
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca