InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GEM

Summary

InnateDB Protein

IDBP-28867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GEM

Protein Name

GTP binding protein overexpressed in skeletal muscle

Synonyms

KIR;

Species

Homo sapiens

Ensembl Protein

ENSP00000297596

InnateDB Gene

IDBG-28865 (GEM)

Protein Structure

UniProt Annotation

Function

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006955	immune response
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0015684	ferrous iron transport
GO:0051276	chromosome organization
GO:0051310	metaphase plate congression

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030496	midbody
GO:0051233	spindle midzone
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR017358 Small GTPase superfamily, GEM/REM/Rad
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF02421
PF08477

PRINTS

PR00449

PIRSF

PIRSF038017

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References