Version 5.4
Homo sapiens Gene: GEM
Summary
InnateDB Gene IDBG-28865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GEM
Gene Name GTP binding protein overexpressed in skeletal muscle
Synonyms KIR
Species Homo sapiens
Ensembl Gene ENSG00000164949
Encoded Proteins
IDBP-28867
GTP binding protein overexpressed in skeletal muscle
IDBP-238029
GTP binding protein overexpressed in skeletal muscle
IDBP-476774
GTP binding protein overexpressed in skeletal muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94249253-94262350
Strand Reverse strand
Band q22.1
Transcripts
ENST00000297596 ENSP00000297596
ENST00000396194 ENSP00000379497
ENST00000523660
ENST00000521817
ENST00000523433 ENSP00000428258
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005525 GTP binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006955 immune response
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0015684 ferrous iron transport
GO:0051276 chromosome organization
GO:0051310 metaphase plate congression
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030496 midbody
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028214
View Gene Order
ENSBTAG00000007596
Not yet available
Cross-References
SwissProt
TrEMBL E5RJF9
UniProt Splice Variant
Entrez Gene 2669
UniGene Hs.597008 Hs.654463
RefSeq NM_005261 NM_181702
HUGO HGNC:4234
OMIM 600164
CCDS CCDS6261
HPRD 11553
IMGT
EMBL AP003478
GenPept
RNA Seq Atlas 2669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca