InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1C2

Summary

InnateDB Protein

IDBP-29076.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1C2

Protein Name

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000272238

InnateDB Gene

IDBG-29072 (ATP6V1C2)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Kidney and placenta. {ECO:0000269PubMed:12384298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0030177	positive regulation of Wnt signaling pathway
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation