InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6V1C2

Summary

InnateDB Gene

IDBG-29072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1C2

Gene Name

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000143882

Encoded Proteins

IDBP-29074

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

IDBP-29076

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:10721649-10785110

Strand

Forward strand

Band

p25.1

Transcripts

ENST00000381661	ENSP00000371077
ENST00000272238	ENSP00000272238
ENST00000480289

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0030177	positive regulation of Wnt signaling pathway
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020566

View Gene Order

ENSBTAG00000001927

Not yet available

Pathways

NETPATH

REACTOME

REACT_25283

Transferrin endocytosis and recycling pathway

REACT_25060

Iron uptake and transport pathway

REACT_1109

Insulin receptor recycling pathway

REACT_498

Signaling by Insulin receptor pathway

REACT_121256

Phagosomal maturation (early endosomal stage) pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_111102

Signal Transduction pathway

REACT_121237

Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway

REACT_116125

Disease pathway

KEGG

hsa05110

Vibrio cholerae infection pathway

hsa05120

Epithelial cell signaling in Helicobacter pylori infection pathway

hsa00190

Oxidative phosphorylation pathway

hsa04966

Collecting duct acid secretion pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q8NEY4

TrEMBL

UniProt Splice Variant

Entrez Gene

245973

UniGene

RefSeq

NM_001039362 NM_144583

HUGO

HGNC:18264

OMIM

CCDS

CCDS1674 CCDS42653

HPRD

IMGT

EMBL

AC092687 AY039759 BC012142

GenPept

AAH12142 AAK83464 AAY24069

RNA Seq Atlas

245973