InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBR1

Summary

InnateDB Protein

IDBP-2913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBR1

Protein Name

carbonyl reductase 1

Synonyms

CBR; hCBR1; SDR21C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000290349

InnateDB Gene

IDBG-2911 (CBR1)

Protein Structure

UniProt Annotation

Function

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269PubMed:15799708, ECO:0000269PubMed:17912391, ECO:0000269PubMed:18449627, ECO:0000269PubMed:18826943}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004090	carbonyl reductase (NADPH) activity
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0047021	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221	prostaglandin-E2 9-reductase activity

Biological Process

GO:0008152	metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0030855	epithelial cell differentiation
GO:0042373	vitamin K metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process