InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CBR1

Summary

InnateDB Gene

IDBG-2911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBR1

Gene Name

carbonyl reductase 1

Synonyms

CBR; hCBR1; SDR21C1

Species

Homo sapiens

Ensembl Gene

ENSG00000159228

Encoded Proteins

IDBP-2913

carbonyl reductase 1

IDBP-231245

carbonyl reductase 1

IDBP-364802

carbonyl reductase 1

IDBP-596282

carbonyl reductase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:36069941-36073166

Strand

Forward strand

Band

q22.12

Transcripts

ENST00000290349	ENSP00000290349
ENST00000399191	ENSP00000382143
ENST00000439427	ENSP00000395132
ENST00000466328
ENST00000530908	ENSP00000434613

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004090	carbonyl reductase (NADPH) activity
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0047021	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221	prostaglandin-E2 9-reductase activity

Biological Process

GO:0008152	metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0030855	epithelial cell differentiation
GO:0042373	vitamin K metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000051483

View Gene Order

ENSBTAG00000023384

Not yet available

Pathways

NETPATH

REACTOME

REACT_150149

Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00590

Arachidonic acid metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

INOH

INOH website

Prostaglandin Leukotriene metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.701445 Hs.88778

RefSeq

NM_001286789 NM_001757

HUGO

OMIM

CCDS

CCDS13641 CCDS68202

HPRD

00267

IMGT

EMBL

GenPept

RNA Seq Atlas