Version 5.4
Homo sapiens Protein: PTCD1
Summary
InnateDB Protein IDBP-29141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTCD1
Protein Name pentatricopeptide repeat domain 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292478
InnateDB Gene IDBG-29139 (PTCD1)
Protein Structure
UniProt Annotation
Function Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. {ECO:0000269PubMed:21857155}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:19651879, ECO:0000269PubMed:21857155}. Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Abundant in testes, skeletal muscle and heart. {ECO:0000269PubMed:19651879}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0042780 tRNA 3'-end processing
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR002885 Pentatricopeptide repeat
PFAM PF01535
PF12854
PF13041
PF13812
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75127
PhosphoSite PhosphoSite-O75127
TrEMBL C9JWL7
UniProt Splice Variant
Entrez Gene 26024
UniGene Hs.632313
RefSeq NP_056360
HUGO HGNC:22198
OMIM 614774
CCDS CCDS34691
HPRD 11463
IMGT
EMBL AB014532 AC004922 AC073063 AC090113 AK291004 BC003688 BC080580 BC103502 CH236956 CH471091
GenPept AAH03688 AAH80580 AAI03503 BAA31607 BAF83693 EAL23880 EAW76669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca