InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRNT1

Summary

InnateDB Protein

IDBP-292453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRNT1

Protein Name

tRNA nucleotidyl transferase, CCA-adding, 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385745

InnateDB Gene

IDBG-13784 (TRNT1)

Protein Structure

UniProt Annotation

Function

Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11256614}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0004810	tRNA adenylyltransferase activity
GO:0005524	ATP binding
GO:0052927	CTP:tRNA cytidylyltransferase activity
GO:0052928	CTP:3'-cytidine-tRNA cytidylyltransferase activity
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity