Version 5.4
Homo sapiens Gene: TRNT1
Summary
InnateDB Gene IDBG-13784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRNT1
Gene Name tRNA nucleotidyl transferase, CCA-adding, 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072756
Encoded Proteins
IDBP-13786
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-13788
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-13790
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-234599
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-292453
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-360735
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-360736
tRNA nucleotidyl transferase, CCA-adding, 1
IDBP-360737
tRNA nucleotidyl transferase, CCA-adding, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the 3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated and to participate in protein biosynthesis (Lizano et al., 2007 [PubMed 17204286]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:3126916-3150879
Strand Forward strand
Band p26.2
Transcripts
ENST00000280591 ENSP00000280591
ENST00000339437 ENSP00000342985
ENST00000251607 ENSP00000251607
ENST00000397779 ENSP00000380881
ENST00000402675 ENSP00000385745
ENST00000434583 ENSP00000415100
ENST00000420393 ENSP00000400394
ENST00000413000 ENSP00000388615
ENST00000465998
ENST00000469632
ENST00000482311
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0004810 tRNA adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0052927 CTP:tRNA cytidylyltransferase activity
GO:0052928 CTP:3'-cytidine-tRNA cytidylyltransferase activity
GO:0052929 ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
Biological Process
GO:0001680 tRNA 3'-terminal CCA addition
GO:0006396 RNA processing
GO:0006626 protein targeting to mitochondrion
GO:0042780 tRNA 3'-end processing
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013736
View Gene Order
ENSBTAG00000019534
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567495 Hs.732725 Hs.732860
RefSeq NM_182916 XM_005265196
HUGO
OMIM
CCDS CCDS2561
HPRD 18227
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca